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Indeed, when nicotine is administered concurrently with a CYP2A6 inhibitor of unknown strength, the substrate metabolism will be reduced, resulting in increasing serum concentrations and heightened risk, incidence, and/or severity of ADRs
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doi:10.1111/j.1439-0310.1974.tb01809.x
In making this move, the makers of Marlborohave carried the fight directly into the enemys camp
