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Compared to subjects who had never smoked, those currently smoking either menthol or non-menthol cigarette brands had similarly high mortality risks (about double) compared to never smokers

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TLR9 antagonist administration before e-cigarette vapor exposure not only mitigated TLR9 upregulation in atherosclerotic plaques but also suppressed the increase in plasma levels of inflammatory cytokines and accumulation of lipids and macrophages in the plaques