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2008 doi: 10.1136/thx.2007.090647

Larcombe A, Allard S, Mullins B

Recently, European Union has developed a new regulation which implements an upper limit of 20 mg/ml nicotine concentration in liquids that are used with ECs 5

Constipation with or without other features of voiding dysfunction was often the initial sign of gastrointestinal involvement, but problems such as hemorrhoids, rectal bleeding, and anal fissures were uncommon and more serious complications such as rectal prolapse or fecal impaction did not occur

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