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No or very little improvement in their symptoms, even after 4 or more weeks of taking a new antidepressant

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Cannabis use disorders in the USA: prevalence, correlates and co-morbidity

Although one meta-analysis of earlier randomized trials had reported an increased risk of CVD events among smokers using varenicline,(137) subsequent larger meta-analyses(129,138140) and several large retrospective cohort studies(141143) found no evidence of a significantly increased CVD risk with varenicline use