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Although they contain fewer harmful substances than traditional tobacco products, some types do contain harmful chemicals including formaldehyde, chromium, and tobacco-specific nitrosamines, which raise concerns about potential long-term health risks

In more severe cases, an allergic reaction could cause difficulty breathing or shortness of breath, requiring immediate medical attention

The specific time frame and magnitude of population health effects of e-cigarettes will depend on their impact on the rates of initiation and cessation of combus- tible tobacco cigarettes and on their intrinsic harm