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Erosions can be seen on the gingival tips The mucosa returns to normal when the condition is in remission Refer to the related chapter Pemphigus vulgaris Paraneoplastic pemphigus Causes severe mucosal erosions and ulcerations Refer to the related chapter Paraneoplastic pemphigus Linear IgA disease Mucosal involvement, which can precede cutaneous signs, is common with bullae and ulceration on the lips and inside the mouth in approximately 50% of cases Lesions may spread to the pharynx Refer to the notes in the section above on trunk / wider distribution Epidermolysis bullosa and e pidermolysis bullosa acquisita Others - drugs reactions and l upus erythematosus Conjunctival erosions / bullae / scarring Erythema multiforme Stevens-Johnson syndrome / toxic epidermal necrolysis Mucous membrane pemphigoid (figure 58) In some cases patients present with conjunctivitis and complain of grittiness or pain

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While propylene glycol alone did not alter ICSS thresholds, co-administration of propylene glycol and nicotine decreased the aversion-associated increase in ICSS thresholds, which was induced by the high dose of nicotine alone (78)