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Vareniclines long track record of efficacy and safety and its approval from FDA as a smoking cessation aid favors it as the first-line choice, but this study indicates that [e-cigarettes] are certainly an option for people who are unsuccessful with or cannot tolerate varenicline, said Nancy Rigotti, director of the Tobacco Research and Treatment Center at Massachusetts General Hospital, who was not involved in the study

doi: 10.1016/S0140-6736(10)61388-8

The antinociceptive response to nicotinic agonists in a mouse model of postoperative pain

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Healthy People 2020