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These events preceded the Syndicate, with this new origin retconning the original series run by claiming that the Smoking Man was in fact playing against the Syndicate, despite having previously being seen taking orders from them

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Nicotine Nicotine is a stimulant found in tobacco and most vaping products, as well as some other products including medicines to help people stop smoking

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"Comprehensive smoke-free legislation in England: how advocacy won the day." Tobacco Control 16.6 (2007): 423-428.online Shahab, Lion, and Robert West