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doi: 10.13344/j.microbiol.china.230593 56 ZhaoX.DongQ.HanY.ZhangK.ShiX.YangX.et al

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In liver cancer, -CBT-diol inhibited the proliferation of HepG2, SMMC-7721 and HL-7702 tumor cells, reduced the formation of carcinoma cell clones, disrupted the cell cycle by significantly increasing S phase, induced cell apoptosis by regulating p53-PUMA, PI3K-Akt, and IL-1-NF-B-IAP pathways (Yuan et al., 2019)