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(Mechanisms) Several interacting biological and behavioral reasons account for greater harms in many outcomes: a) Sex hormones and nicotine/carcinogen metabolism Women metabolize nicotine faster (on average) than men, largely because estrogen upregulates the liver enzyme CYP2A6

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In parallel to autophagy, intracellular damage can activate an interconnected response known as unfolded protein response (UPR), which is induced by reticulum stress (79)

Jimmy did about everything he possibly could until he couldn't do it anymore

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