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Flash - a new medical study was released in May 2002 indicating that heavy nicotine use may actually destroy brain cells and diminish concentration and memory

Brunnemann KD and Hoffmann D

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Notably, an in silico PK approach may be the only feasible option to estimate the nicotine and cotinine concentration in fetuses for ethical concerns
There is a significant risk that unless the marketing is very carefully circumscribed, they will become the next trend and the next fad. Even those who are open-minded about IQOS dont think itll solve Americas tobacco problem