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There have been postmarketing reports of new or worsening seizures in patients treated with CHANTIX [see Warnings and Precautions (5.2)]

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This classic approach has been commonly applied 35,36,37,38,39 and has key advantages 26 , including that it is relatively fast to apply and is more interpretable compared to more sophisticated methods, such as Bayesian regression models that perform shrinkage 39,40,41

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