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However, they theorize that several factors may play a part, including: genetics environmental factors, such as exposure to allergens changes to a persons immune system A combination of these factors may lead to changes in the functioning of a persons skin barrier, which is the outermost layer of skin

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Mold, dust, and chemical residues may be present without detection

Since Japan restricts the sale of nicotine-containing e-liquids, many users opt for non-nicotine versions or import their own