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The toxins from smoking can put additional stress on the liver and other organs responsible for detoxification

they look for metabolites

These include: increased risk of oral cancer gum disease stained teeth bad breath (halitosis/oral malodour) tooth loss loss of taste and smell reduced blood supply to the mouth increased build-up of plaque biofilm and tartar on your teeth delayed healing following tooth extraction and other surgery in the mouth Current evidence indicates tobacco and alcohol together significantly increase the risk of mouth and throat cancers compared with either alcohol or tobacco use alone

Orr 2014

Latin America E-Cigarette Market Revenues & Volume, 2015-2025F ($ Million, Million Units) Figure 42