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Wyss revealed that American men had zero excess mouth cancers associated with [low-nitrosamine] dipping or chewing tobacco (Odds Ratio, OR = 0.9), while women, who mainly use[d] [high-nitrosamine] powdered dry snuff, had a 9-fold elevated risk ( here )

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model

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Psychopharmacology 143 , 158165 (1999)

The research team found mutational signatures, or molecular fingerprints of DNA damage, in the smokers DNA, counting how many of these specific mutations were found in the different tumors