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Over time this can lead to a reduction in the number of nicotine receptors in the brain - and it is the large number of these receptors in smokers that contributes to withdrawal because the activation of these receptors is what triggers the effects of nicotine

Carcinogenesis (2003) 24(10):165763.10.1093/carcin/bgg101 13 AntonyJGopalanVSmithRALamAK

however, no differences were found in the levels of exhaled carbon monoxide (CO), an oxidative stress marker, before and after e-cigarette consumption [8]

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