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During an attack, the affected joint becomes hot, swollen, and exquisitely tender, making even the lightest touch or the weight of a bedsheet unbearable

Now, however, some historians seriously doubt the charming lucky accident story, partly because it appeared so many years after the event was said to have happened.[3] It is true that Stephens enslaver, Abisha Slade, and his brothers became known for their work in developing bright leaf, however

These adverse effects on the immune system not only occur in active smokers, but also in those exposed to smoke passively in contaminated environments, and may persist for decades after exposure has ended

Atlanta GA: National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health, 2012

Ambient air pollution: a global assessment of exposure and burden of disease