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New evidence suggests that nicotine-based e-cigarettes may increase the risk of some cancers, according to a recently published review in the journal Carcinogenesis

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However, aggressive lobbying by the tobacco industry and the rise of alternative nicotine delivery systems (ENDS) are significant threats that persist

This review aims to synthesize the current understanding of nicotine pouches, focusing specifically on the potential cardiovascular risks they pose to teens and young adults

Despite the obvious biologic plausibility, the lack of consistent epidemiological evidence might be due to methodological issues including lack of cohort follow-up time into older adulthood (when lung cancer usually becomes clinically manifest), small sample sizes, selection and recall biases, and lack of adjustment for tobacco use in the statistical modeling