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Through this mechanism, nicotine is thought to increase dopamine levels in the striatum via the mesolimbic pathway, which reduces the dopamine receptor blockade caused by antipsychotics and results in an improvement of extrapyramidal side-effects (Laruelle Reference Laruelle2014)

Wolkin: Was there a lot of pressure for you to smoke in social situations, whenever you would go out partying or at the track

however, upon activation, the regulatory cytosolic subunits translocate to the membrane, where they interface with the membrane-bound catalytic subunits

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Together, these actions represent powerful, science-based approaches that will have an extraordinary public health impact