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A recent review of drug options for tobacco dependence noted: The pharmacological effect of nicotine plays a crucial role in tobacco addiction, and therefore pharmacotherapy is important to address this component of tobacco dependence in order to improve success rates. 1 A global market of around 650 million potential customers is an alluring prospect for pharmaceutical companies, yet there are just three major options for drug-aided smoking cessation: various nicotine replacement therapies and the drugs bupropion and varenicline