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It took effect in 2005 and the 181 countries that have ratified the FCTC have agreed to adopt its package of tobacco control measures.(99,100) The MPOWER acronym was introduced to help countries implement these policies (Table 2).(101) The implementation of the FCTC has been associated with increased adoption of advertising bans(102) and smoke-free legislation.(103) Countries that implemented the measures to reduce demand at the highest level have observed reductions in smoking prevalence.(104) However, some countries have yet to implement any of these measures, and the U.S

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Notably, sputum M1 macrophage frequencies did not associate with impaired lung function, unlike neutrophil counts (Supplementary Fig

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