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WRKY is a key gene in the biological stress response and SA, JA signaling 44,45,46

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7 In another study that accessed the extant health records of the Danish population, researchers reported that the population attributable risk fraction for cannabis use disorder in schizophrenia has markedly increased over time, from 2% in the early 1970s to almost 30% in males aged 2125 by 2020, corresponding to an adjusted incidence hazard ratio of nearly 3.0, which the authors contend is consistent with increases in its availability and potency, and consistent with the rising incidence of schizophrenia

33 Anhedonia the feeling that there is little pleasure in life can also occur with withdrawal from nicotine, and from other drugs of abuse