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The observed rise in cotinine concentration (~ 0.2% of nicotine measured concentration) in the PBS can be explained by its presence in the tobacco leaves 56 , whilst there is no direct explanation for the observed OH-cotinine in the PBS (~ 0.02% of nicotine concentration) (Supplementary Fig

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Dental evaluation may be indicated in challenging cases, although this is rare
One of the widely used treatments to help with quitting is Nicotine replacement therapy (NRT)

Korean J Fam Med