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Long-term drug abuse effects include : Cancer Heart disease Lung disease Infertility Liver damage Memory loss and other types of impaired cognition Central nervous system damage Paralysis Kidney failure Overdose Fatality On a social level, you can lose your job, get into trouble with law enforcement and the court system, and lack financial resources for everyday expenses

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Mechanisms of Carcinogenesis Mutational Signatures Research into the mutational signatures associated with tobacco smoking reveals complex patterns of DNA damage