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PEGylation has been demonstrated to impart stealth properties, such as increasing systemic circulation time, decreasing serum protein adsorption, and reducing interactions with cells of the MPS ( ) and Merrimacks liposomal irinotecan (Onivyde )both nanoparticle formulations are used for cancer therapy ( In this work, we examined tobacco mosaic virus (TMV), a plant virus nanoparticle (VNP), as a nanocarrier platform