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Furthermore, additional beneficial effects may be obtained when niacin is combined with rutin (a chemical found in botanicals), which is considered effective in reducing and preventing capillary fragility.105 The patent went on to state that niacin and rutin may also be incorporated in a smoking composition which is made from vegetable materials other than nicotine-containing tobacco and de-nicotinized tobacco.105 It was noted that both compounds should be in the range of 0.1% to 2.5% by weight of the cigarette.105 It is not known whether cigarettes were ever manipulated to have that concentration range of those chemicals