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1 In addition to tobacco which is loaded with harmful substances, cigarettes also consist of paper wrapping and a filter, and theyre packaged in plastic, aluminum foil, and paper cartons and shipped in cardboard boxes

Many people report mood swings or moments of frustration as their bodies adapt to life without cigarettes

Withdrawal is characterized by negative affective states (irritability, anxiety, depression, anhedonia) and craving, partly mediated by dopamine deficits and activation of stress pathways involving corticotropin releasing factor

Annual review of neuroscience, 34, 105130