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In general, the indications for treatment are: Falling hemoglobin or platelet count Progression to a later stage of disease Painful, disease-related overgrowth of lymph nodes or spleen An increase in the rate of lymphocyte production [66] Treatment approach [edit] Most CLL cases are incurable by present treatments, so treatment is directed towards suppressing the disease for many years, rather than curing it

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Unlike the fixed physiological effects of combustible tobacco (where smoke damages the airways permanently), nicotine pouch dehydration effects are transient and respond directly to water intake

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