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Discussion Given the critical role of mitochondrial function in the pathophysiology of COPD and its reported association with nDNA methylation, we set out to explore the effect of cigarette smoke exposure on DNA methylation of the mitochondrial genome

The magnitude of and evidence for the associations between smoking and its leading health outcomes are among the highest currently analyzed in the burden-of-proof framework 29

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A large part of that was the cyanide

and was critical of some of the aesthetics