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Similarly, in vivo and in vitro data also support that acute exposure to aerosolized PG:VG increases Mucin-5AC (MUC5AC) protein levels [34], a major airway gel forming protein known for its role in preventing infections [35] and a biomarker for COPD severity [36]

Funding The authors would like to thank the Algerian Directorate General for Scientific Research and Technological Development (DGRSDT) and the Thematic Research Agency in Health Sciences (ATRSS) for the support of this research work via PNR project (33/DFPR/ATRSS)

Rigotti is director of the Massachusetts General Hospital Tobacco Research and Treatment Center

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