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However, the correlation between Stat3 and Socs3 was significant, which may suggest the important role of the JAKSTAT signaling pathway in lung injury caused by vapor or smoke exposure ( We previously reported structural lung damage in rats exposed to smoke or vapor, characterized by alveolar collapse, thickened alveolar septa, and mucus accumulation in bronchioles

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[2] [10] while the American version of the brand has faced steadily declining sales, dropping to sixth place by 2005 in the last national survey