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This variation obviously depends on the device, the puff duration, and other aspects when accurately determining nicotine equivalence

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Thats bordering the line of tobacco dependence

10.1007/s11101-022-09812-5

If youre in a region where vapes have a maximum nicotine strength of 20 mg/ml, you may need to take more than 300 puffs per day to equal a pack of cigarettes