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A meta-analysis of statins in primary or secondary prevention of stroke found that for each 1 mmol/L (or approximately 39 mg/dL) reduction in LDL cholesterol level, a 21% relative reduction in stroke risk was achieved.13 The Stroke Prevention by Aggressive Reduction of Cholesterol Levels (SPARCL) trial randomized patients with stroke or TIA within 6 months who had LDL-cholesterol levels between 100 mg/dL and 190 mg/dL, and without evident coronary artery disease to atorvastatin 80 mg daily or placebo

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