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The studies analyzed consistently highlight adolescence as a critical period of neurobiological maturationparticularly within the prefrontal cortex and limbic regions that regulate cognition, emotion, and decision-makingduring which nicotine exposure may confer heightened vulnerability ( Nicotine acts on nicotinic acetylcholine receptors, affecting neurotransmission and synaptic plasticity

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Available from: health-canada/services/health-concerns/tobacco/legislation/tobacco-product-labelling/smoking-mortality.html#a1 Canadian Cancer Society

Sixteen percent suggest an age older than 21, and 4% say "never." Think Before You Drink Like tobacco, there is a clear-cut age for the legal consumption of alcohol -- 21

The exact amount of nicotine varies by brand