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The Framers of the Constitution and other Americans of that era understood all of this quite well

No wonder I was coughing so much before I got those Moose Labs filters

Peck (1810). Journal of Supreme Court History 42 (3): 23955

That is "Fire Cured" Tobacco
Feynman had his revenge a few years later, when Heisenberg concluded an entire book on cosmic rays with the phrase: "such an effect is not to be expected according to Vallarta and Feynman"