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Whilst some non-HPHC chemical constituents have been identified in aerosols from heated tobacco products at levels higher than those observed with conventional cigarette mainstream smoke, or have been quantified in aerosols from heated tobacco products but not in conventional cigarette mainstream smoke at all, the significance of these analytical observations to the toxicological profile of heated tobacco products remains unknown and requires further investigation (St Helen et al., 2018)

doi: 10.1007/s00213-009-1716-z

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In particular, HR, SBP, DBP and PWV were altered in subjects who acutely inhaled nicotine-containing e-cigarette aerosols