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nAChRs and cytokine storm The postulated mechanism for the efficacy of nicotine in infectious diseases in general, and in COVID19 in particular, includes restoring and reactivating the cholinergic antiinflammatory pathway that can suppress the cytokine storm, also referred to as macrophage activation syndrome [18, 59]

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Esposito M, Mainstream smoke constituents and in vitro toxicity comparative analysis of 3R4F and 1R6F reference cigarettes