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Analyses have revealed that the activity and expression levels of SOD and catalase are diminished in alveolar macrophages [191], erythrocytes [55], circulating progenitor cells [194], and blood serum [56] of smokers

Cancer Res, 49: 3063-3069

Over time, the confluence of these effects can cause damage to the lining itself and even potentially to the DNA of the epithelial cells
