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The following toxic chemicals and metals have been found in e-cigarettes: Nicotine- Highly addictive and can negatively impact the adolescent brain development Propylene glycol- Common additive in food but also used to make antifreeze, paint solvent, and artificial smoke Carcinogens- Chemicals known to cause cancer Acrolein- A herbicide used to kill weeds and known to cause irreversible lung damage Diacetyl- A chemical linked to lung disease known as bronchiolitis Obliterans or popcorn lung Diethylene Glycol- A toxic chemical used in antifreeze Cadmium- A toxic chemical found in traditional cigarettes that causes breathing problems Benzene - A volatile organic compound found in car exhaust Additional items- Heavy metals such as nickel, tin, and lead & Ultra fine particles that can be inhaled deep into the lungs These chemicals can produce irreversible damage to an adolescents developing lungs What are the health effects of E-cigarettes

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Its efficacy has been confirmed in a phase 3 clinical trial for RR-TB, thus representing a key component of the shortened treatment regimen for DS-TB (Sarathy et al., 2019