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The major part of the nicotine is not ionized, so it can easily pass through cell membranes

Study Limitations and Public Health Implications This study provides the first evidence connecting HTPs and cigarette exposure to elevated circulating LPS and zonulin in both children and adults, implying intestinal barrier dysfunction and cardiovascular risk

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The value of is -0.029 for males and -0.035 for females, -0.036 for both smokers and ex-smokers and, slightly lower, -0.033, for non-smokers, indicating that the perception of odor intensity decreases for both sexes and independently of the smoking habits with age, but the rate of this decrease is slightly higher in the case of females and in the case of smokers and ex-smokers compared to non-smokers