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We then multiplied the lifetime risk of cancer in never-smoking non-drinkers by the percentage increase in RR (calculated as: (RR-1)*100) of drinking ten (approximately one bottle of wine) and 30 (approximately three bottles of wine) units of alcohol per week (Alcohol Attributable Fraction for England 2008) [28] (Additional file 1: Table S1) to estimate the increase in absolute lifetime risk (expressed as a percentage) of developing cancer for this level of consumption in non-smokers (Fig

Degradation of mutp53 Mutp53 can form stable aggregates that accumulate in cells and play an important role in cancer progression [145]