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Riyi Shi 1,2 1 Department of Basic Medical Sciences, College of Veterinary Medicine, 2 Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN Corresponding author: Riyi Shi, 765-496-3018, [email protected] Acrolein, an ,-unsaturated aldehyde associated with oxidative stress, is also a major toxic component of tobacco cigarette smoke, which has been reported in the clinic to coincide with the exacerbation of neuropathic pain after SCI