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The contraceptive implant is generally safe, but the following conditions can make it unsafe for you: Cigarette smoking Sexually transmitted diseases (STDs) Obesity Hypertension (high blood pressure) Hyperlipidemia (high lipid or cholesterol levels) Deep vein thrombosis (blood clot in the deep veins of your legs) Pulmonary embolism (blood clot in the big vein supplying blood to the lungs) Rheumatoid arthritis Anemia Epilepsy Thyroid disease Diabetes mellitus History of bariatric surgery Abortion in the first or second trimester SLIDESHOW See Slideshow When can you get Nexplanon inserted