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p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa
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J Neurosci Res
The development of GEMMs has allowed for insights into the biology of p53 mutant cancers, as they reliably mimic the oncogenic mutations underpinning cancer formation in humans and hence enable the study of the impact of specific oncogenic driver events
