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While its been deemed safe as a topical or oral agent, the chemical seems to cause harm when inhaled

Nearly three-quarters of the patients with the tobacco habit had oral mucosal lesions, ST users tend to have more severe gingival recession (REC) and clinical attachment loss (CAL) and a greater proportion of sites with higher values of REC and CAL compared with never-users

Aquatic pets such as fish are also affected as cigarette smoke and its toxins can dissolve in fish tanks

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