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In addition, Li-Fraumeni patients with certain hotspot p53 mutations, such as R248Q, show earlier onset of malignant disease compared with patients that harbour mutations that cause a loss of p53 protein [96]
Pe-Cons No/Yy - 2012/0366 (Cod) 2014
Chang YC, Hu CC, Tseng TH, Tai KW, Lii CK, Chou MY
Slagle, B
