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cigarette smoke induces cytoplasmic p53 accumulation Tobacco carcinogens, DNA damage and mutations in smoking-associated cancers The role of p53-mediated signaling
Description
This inhibition of AKT/mTOR, in combination with transactivation of damage-regulated autophagy modulators, guides the p53-mediated elimination of damaged cellular components by autophagic clearance

10.1073/pnas.81.5.1327 11 DoghishA

Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner

(2015) 104:736743.e736

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