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Figure 4 3.4 Nicotine and fluoxetine alter regional 5-HT 1A R activity in adolescent rats Given behavioral evidence of changes in 5-HT 1A receptor activity following pretreatment with fluoxetine or nicotine in adolescents, we used a neuroanatomical approach to assess the regional specificity of these functional effects ( Supplementary Table 1 )

Female rats display dose-dependent differences to the rewarding and aversive effects of nicotine in an age-, hormone-, and sex-dependent manner

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Teenagers, even middle school kids are using these products with bubble gum flavors or cinnamon flavors

But more study is needed to confirm this link