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During 20152019, cigarette-only use declined, while cannabis-only use increased across nearly all sociodemographic groups. Cigarette-only use was most prevalent among socioeconomically disadvantaged adults (with lower education, income, or lacking insurance), the study found, whereas cannabis-only use predominated among more socioeconomically advantaged groups (college-educated, high-income, and privately insured). While prior studies have concluded that marijuana smoke exposure is not equally or more dangerous to health than tobacco smoking, the authors of the new paper suggested that the surge in cannabis use as tobacco use wanes represents a worrisome trend among adults. Without timely policy response, cannabis may become the next public health crisis, they cautioned

Nicotine release profiles were compared by calculating the difference factor (f1) and similarity factor (f2) by adopting methodology referenced in Guidance for Industry from FDAs Center for Drug Evaluation and Research (CDER)