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Co-administration with other drugs that are metabolized by CYP 3A4 (e.g., indinavir, erythromycin) may increase their clearance, resulting in decreased plasma concentration

Importantly, the mice pre-exposed to nicotine showed significantly increased number of neutrophils in circulation and in the lungs before injection of cancer cells (premetastatic lung), and their numbers progressively increased during metastatic outgrowth (metastatic lung) after intravenous tumor implantation (Fig